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Design and validation of the first cell-impermeant melatonin receptor agonist

Adverse effects of exogenous melatonin supplements appear to be limited to headache, dizziness, and drowsiness that may mislead the patients to believe that melatonin supplements are generally safe, whereas it has been found that those carrying copies of the G allele where pancreatic expression of MTNR1B is increased may show impaired postprandial glucose disposal under the impact of melatonin