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For instance, a study published in the Journal of Applied Toxicology found that patients with rheumatoid arthritis had lower levels of glutathione compared to healthy individuals

First, the complex formed following covalent modification of -syn by 4-HNE (4-HNE/ -syn) tends to form more oligomers and fibrils than the simple -syn, subsequently forming amyloid fibers that increase the toxicity to dopaminergic neurons [61, 82]

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