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Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis

Uricosuric agents like dotinurad enhance UA excretion by targeting specific enzymes involved in purine metabolism

In the trioLR analyses, we relied on permutation testing to gage whether signals occurred by chance, and again encourage both replication and biological plausibility as additional milestones for validation