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Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression

Research indicates that silibinin can reduce the levels of miRNAs ( miR-125b , miR-182 , and miR-20b ), and up-regulate the levels of pro-apoptotic genes ( p53 , Bax , Caspase-9 , PTEN , and Bcl2L11 ), decrease the level of anti-apoptotic gene ( Bcl-2 ), thereby inducing apoptosis in breast cancer cells (T-47D, MCF-7, and MDA-MB-231) [947, 954]

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Because the strategy lacks platelet-specific functions such as clot retraction and amplification mechanisms driven by platelet secretion, their ability to sustain long-term haemostasis is inherently incomplete, as reflected by occasional rebleeding in the tail-laceration assay (Supplementary Fig