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2.7 Alteration of gut microbiota composition The mechanisms through which probiotics exert these effects are multifaceted and include competitive exclusion of pathogens, production of antimicrobial metabolites (e.g., bacteriocins and short-chain fatty acids), modulation of local pH, enhancement of mucosal barrier integrity, and immunomodulation (2, 33, 35)

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A verificao analtica geralmente inclui cromatografia lquida de alta eficincia (HPLC) e espectrometria de massa para confirmar a identidade, a pureza e a consistncia do lote do peptdeo antes da aplicao experimental

Mucous solids and liquid secretion by airways: studies with normal pig, cystic fibrosis human, and non-cystic fibrosis human bronchi