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Some infections that may cause a metallic taste in the mouth and feeling sick may include: common cold oral infections and inflammation, such as a tooth cavity, gingivitis, or dental abscesses bacterial infections fungal infections COVID-19 the flu HIV hepatitis sinusitis Lyme disease Hansens disease syphilis Other symptoms can vary based on the type of infection, but may include: runny nose stuffy nose facial pain headaches postnasal drip ear pain cough fever chills difficulty breathing body aches Treatment Treatment will depend on the type of infection, but may include: drinking plenty of fluids, such as water, herbal tea, and broth getting plenty of rest gargling with saltwater taking OTC pain relievers and decongestants taking prescribed medications, such as antibiotics A wide variety of medications can lead to a metallic taste in your mouth as a side effect