melanotic macule treatment of labial macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Labial Melanotic Macules - DoveMed

Hence, it would be equally important to deepen investigations related to other clinical phases like hypomania/mania and mixed features, also differencing between type I and type II BD

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In another study, it was shown that dietary L-theanine (600 mg/kg) supplementation improved the FCR and BW of broilers, and mitigated transport stress by increasing the lymphoid organ index (thymus, spleen, and bursa of Fabricius), muscle antioxidant activity (T-AOC, CAT, and GSH-PX) and meat quality indices (decreased drip loss, muscle MDA, PC, and lactate contents) [80]

this result serves as an evidence for LDR-induced endothelial inflammation (Wang et al., 2019)