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However, factors such as diet, lifestyle, and environmental exposure may impact glutathione levels

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25 , 26 , 31-37 In an often quoted DACOTA randomized clinical trial comparing HU (N=86) to DAC (N=84), overall responses were 35% and 63%, respectively, median OS 18.4 and 21.9 months, median event-free survival 10.3 and 12.1 months, and 2-year BT rates 38.4% and 60.7%

The elevated BCAAs catabolism in NSCLC cells suppresses m6A demethylase ALKBH5 expression, thereby promoting epithelial-mesenchymal transition and tumor metastasis (Mao et al., 2024)