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Blocking this antioxidant axis with SLC7A11 and GPX4 inhibitors (ferroptosis inducers) such as the small-molecule Erastin and RSL3, respectively, leads to uncontrolled accumulation of lipid peroxides at the plasma membrane and other endomembranes within the cell, which promotes membrane permeabilization, damages membrane integrity and ultimately induces ferroptosis [34, 38]

What we do have is a coherent but indirect body of evidence

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Genes were scored in batches of up to 10 using the following prompt: For the following genes: [list symbols of up to 10 genes] 1