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These mechanisms include: (1) hyperglycemia induces an imbalance in the redox state of iron ions, promoting free radical generation and accelerating ferroptosis ( 2.2 Impact of iron homeostasis imbalance on ferroptosis in DCM and molecular regulatory mechanisms Iron homeostasis refers is the regulation of iron intake, transport, storage, and excretion, which directly impacts cellular energy metabolism, antioxidant defense, and immune responses ( In DCM, blood glucose dysregulation triggers excessive oxidative stress and chronic inflammation, both of which are major contributors to ferroptosis (59)

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Since then, CDDO-ME has been investigated to develop novel medicines against diabetic nephropathy, for which no effective medicine has been established despite its high morbidity [113,114]

Exopolysaccharide-repressing small molecules with antibiofilm and antivirulence activity against Pseudomonas aeruginosa