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Berg CP, Engels IH, Rothbart A, Lauber K, Renz A, Schlosser SF, et al

For example, targeting TXNIP can suppress NLRP3 inflammasome activation, offering a promising anti-inflammatory strategy (184)

Tau protein hypothesis Besides the A protein deposition, hyperphosphorylated or abnormally phosphorylated Tau protein aggregated into neuronal neurofibrillary tangles is also one of the primary pathogeneses of AD [35,36,37]

It is characterized by rapid neuronal death and extracellular matrix degradation post-injury, culminating in cavity formation and long-term neurological deficits (217, 218)