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Moreover, the secretion of IFN by CD8 + T cells can effectively coordinate the suppression of SLC7A11 expression, thereby activating the ferroptosis pathway, which enhances the antitumor immunotherapeutic effect of anti-PD-L1 antibodies [144]

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The inhibition of 12/15-LOX by esculetin leads to diminished levels of HODE and HETE, metabolites that play a critical role in promoting inflammation and further damage to structural cells of the lung [104]

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