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The drug contains the phytocomplex, ie the set of active ingredients that characterize the properties of the plant, which can not be reproduced by chemical synthesis

350 However, the protective effect of high-fiber diet may be reversed if there exists colonization of Prevotella copri , which leads to the overproduction of organic acids, including fumarate and succinate, during the digestion of complex fibers and the promotion of proinflammatory responses in macrophages, exacerbating arthritis in an RA model

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Furthermore, intestinal epithelial cells in CD patients exhibit marked overexpression of vacuolar protein sorting 4B (VPS4B) and glycinamide ribonucleotide formyltransferase (GART), both of which modulate apoptotic processes through p38 MAPK pathway activation [55, 56]