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Palanidurai S, Phua J, Chan YH, et al

MSM also contributes to healthy skin by supporting collagen production, which enhances skin elasticity and appearance

Although bitopertins selectivity for GlyT1 may not have provided sufficient synaptic glycine elevation in relevant cortical areas or may have induced compensatory mechanisms that attenuated its efficacy, iclepertin (BI 425809), which was developed following the bitopertin setback, showed promise in early trials and even reached phase III (Reuteman-Fowler et al