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Description

IDH1 is a cytosolic enzyme that metabolizes isocitrate to -KG to generate cytosolic NADPH

Compounds showed CC 50 values of 14.03 M and higher than 30 M, respectively, which implied SI values of 8.5 and 13.1 for compound 72 and 5.8 and 9.1 for compound 73 , against L

Whole body-ethyl acetate (WBEA), whole body-butanol (WBBU), and body wall-ethyl acetate are extracts of the sea cucumber Holothuria scabra (BWEA)

Additionally, for various pathological conditions, including neurodegeneration, lysosomal and autophagy dysfunction occur concomitantly and both contribute to the disease progression [38,39], further supporting the close connection between lysosomal dysfunction and autophagy inhibition