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159 The receptor inhibitor tocilizumab is an available IL-6 inhibitor with confirmed efficacy in rheumatoid arthritis, but clinical trials in COPD require further study

New England Journal of Medicine 347:1025-1026, 2002

Previous reports have shown T-cell-mediated cytotoxicity is highly sensitive to even small changes on the immune synapse formation by bispecific T-cell engagers 34,35 and it is likely that albumin could cause interference in the efficiency of immune synapse formation or signalling 32 , although its potential impact on the functionality of binding domains also cannot be ruled out

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