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Irp2 / mice displayed neurodegeneration which most adversely affected motor neurons (Jeong et al

Reduced peptide production can affect recovery speed, immune system performance, hormonal balance, and overall vitality

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It is believed that protein and micronutrient deficiencies in early childhood impair pancreatic development and -cell function, ultimately reducing insulin secretion through pathways involving oxidative stress-induced -cell apoptosis and epigenetic alterations in key transcriptional regulators of insulin gene expression, such as PDX1 and MafA [144,145,146] The recognition of Type 5 diabetes highlights undernutrition as an independent mechanistic driver of metabolic disease and reinforcing the need for nutritional and context-specific therapeutic strategies in affected populations