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Although a huge number of experimental and preclinical investigations have provided encouraging results, clinical trials must be performed and completed to definitely evaluate the usefulness and risks of targeting IGF-1R as an option in cancer treatment of humans

Screening of overlap genes and functional annotation In this study, the R package limma was used to calculate the fold change value of gene expression level to uncover the overlapping genes of various SAAM groups

However, unfortunately, although in vitro and in vivo experiments have clarified Fer-1s protective effect on the DR retina and its ferroptosis-regulating mechanism, corroborating the clinical potential of ferroptosis-targeted intervention, critical limitations remain in its targeting specificity, potential off-target risks and clinical translational potential of preclinical models

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