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The GRAS determination was likely based on the compound's limited systemic absorption (when ingested), short plasma half-life, and lack of acute toxicity signals in the Phase 2b obesity trial

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Lastly, she says that people with gastrointestinal disorders such as pernicious anemia, celiac disease, Crohn's disease or those taking specific medications may experience impaired B12 absorption, and proper supplementation can help maintain optimal levels