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Preclinical studies exploring the synergistic effects of such combinations are also essential for advancing this approach

doi: 10.1155/2020/6782872

These discrepancies might be explained and reconciled by recent studies, which demonstrated that after amino acid deprivation, the proteasome moves from its predominant location in the nucleus to the cytoplasm, promoting protein degradation in the cytoplasm and thereby supplying the amino acids necessary for cell survival