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607 Clausenamide, an alkaloid isolated from Clausena lansium , interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment

For instance, cell-mediated immunity is the predominant mechanism by which replication of HCMV is controlled and severe HCMV disease predominantly occurs in patients with profound cellular immunodeficiency 18,19,20

Even between disease flares, low-level inflammation irritates and damages intestinal tissue, which can lead to malignancy

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