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The postoperative perfusion in renal tissue is reduced, and the compensatory blood volume in the kidney is increased, which dilates the entering arterioles and constricts the exiting arterioles, thereby maintaining glomerular filtration, leading to renal medullary ischemia and triggering AKI

A healthy and balanced diet is, among other things, a source of vitamins, minerals, and phytochemicals, which not only have cardioprotective effects but also can reduce OS and inflammation, playing a role in LC development

A P value less than.05 was considered statistically significant

Participants with 1% Ki-67 expression as scored on immunohistochemistry by central pathology review at the Department of Pathology of LUMC, were randomized between standard neoadjuvant chemotherapy or received neoadjuvant letrozole at 2.5 mg daily plus intermitted treatment with ribociclib (600 mg per day on days 121 of a 4-week cycle for 20 weeks for five cycles) followed by surgery