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These results indicate that VNS can effectively improve the mitochondrial morphological changes and mitigate mitochondrial damage in cardiomyocytes induced by hepatic ischemiareperfusion injury, while erastin can counteract this protective effect

H.MahmoodA.AlshamraniA

& Stout, R

Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation