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Indeed, FR nuclear internalization increases the expression of genes associated with the pluripotent neuronal state, including those involved in transcriptional regulation, growth factor signaling, G-protein activity, and cell proliferation

Among other things, the process of rapid brain growth is at this stage [118,119]

Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain