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As mentioned above, loading potentiometric dyes into live cells requires optimization and careful consideration of loading conditions

While the efficacy data did not survive the Phase IIb primary endpoint, the safety dataset across 900 participants is unusual for a research peptide and is consistently cited as the basis for continued investigational interest

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A recent animal experiment demonstrated that inulin-type fructans (ITFs) supplementation induced the expansion of acetate-generating bacteria, especially the genera Akkermansia and Candidatus Saccharimonas , and improved renal function, glomerular injury and renal fibrosis in db/db mice (Luo L