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Furthermore, accurately assessing oxidative stress and metabolic changes in lesions before the ferroptosis-related drugs chosen in patients with comorbidities need to be further investigated

The very potent carcinogens 7,12-dimethylbenz[ a ]anthracene [58] and dibenzo[ a,l ]pyrene [59, 60] form predominantly depurinating Ade adducts and induce an A to T transversion in codon 61 of the H- ras oncogene