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Luczkowska K, Stekelenburg C, Sloan-Bna F, et al

It was first identified in the early 1970s by Dr

Consequently, deficiencies in any of these processes caused by the loss of ATM could be used as therapeutic targets.1110 Consistent with this notion, ATM-null CLL cells are defective in homologous recombination repair (HRR), a deficiency that can be exploited to induce tumor-specific killing via enhanced requirement for HRR upon PARP-inhibition.11 ATM is also implicated in redox homeostasis.12 Deregulation of redox homeostasis results in oxidative stress and occurs either due to increased reactive oxygen species (ROS) production or reduced antioxidant capacity