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For example, it has been shown that an increase in GSSG levels is required for the activation of defense signaling in response to infections by powdery mildews and bacteria ( The fact that GSH overproduction restores wild type levels of TMV resistance in SA-deficient NahG tobacco implies that GSH and SA may induce partially overlapping defense pathways and high levels of GSH may confer TMV resistance by enhancing normal SA accumulation in wild type plants