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2 The intrinsic resistance is mediated by the inherent or endogenous characteristics that are exist in tumor cells or tissues prior to initial treatment, such as effective DNA damage repair mechanisms, tumor growth kinetics and stem cell like properties, that offer cancer cells survival benefits and ability to adapt to primary therapeutic stress

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of Biological and Biomedical Sciences, The Aga Khan Univ., Karachi, 5 Mohi Uddin Islamic Medical College, Mirpur Azad Jammu and Kashmir, 6 Quaid e Azam Medical College, Bahawalpur, Pakistan Objective: Postgraduate trainees (PGs) trained via a multidisciplinary model receive collaborative learning opportunities from a wide range of experts