neelakantan et al. biochemical pharmacology 2019 5-amino-1mq

neelakantan et al. biochemical pharmacology 2019 5-amino-1mq NNMT Inhibitor Roles of Nicotinamide N-Methyltransferase in

Name: neelakantan et al. biochemical pharmacology 2019 5-amino-1mq NNMT Inhibitor Roles of Nicotinamide N-Methyltransferase in
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Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear