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Other Risks Fluoxetine has been associated with other health complications, such as: Difficulty concentrating and impaired judgment, thinking, and motor skills Anxiety and insomnia Changes in appetite and significant weight loss Bleeding problems, including gastrointestinal bleeding Serious medical problems such as angle-closure glaucoma Hyponatremia (low sodium levels) QT prolongation and ventricular arrhythmia Changes in sexual ability Priapism (painful or prolonged erection) Only 1% of maternal use of SSRIs has been linked to persistent pulmonary hypertension of the newborn, a fatal condition associated with the use of antidepressants during the second half of pregnancy

The pharmacokinetics of bupropion, which is extensively metabolized by the CYP450 (CYP2B6), was not affected by moderate (~ 0.30.4 g/L) nor by high (~0.8 g/L) BACs (276)

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