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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

The problem is not the skin alone but how the muscles, connective tissue and fat cells interact with other

furthermore, exogenous NAD + impacts processes such as DNA replication 118