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Animal models help to understand the complex interplay between the different cell types of the CNS and uncover general mechanisms of damage and repair of myelin sheaths

However, following a stroke, the rapid onset of oxygen and glucose deprivation leads to endothelial cell dysfunction, degradation of tight junction proteins (such as claudins and occludins), and activation of matrix metalloproteinases (MMPs), particularly MMP-9 (73, 74)

This review summarizes the biological mechanisms of ferroptosis, analyzes the regulatory factors of ferroptosis in lung cancer cells and their interaction with the tumor microenvironment, and further explores potential therapeutic strategies targeting ferroptosis

LZ: Data curation, Writingoriginal draft