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[30] This metabolic pathway results in the formation of several metabolites, though the parent compound appears to be primarily responsible for the observed antiemetic effects

The defining characteristic of IGF-1 LR3 is it markedly reduced binding affinity for IGF-binding proteins (IGFBPs)

The possible reason for the inconsistent findings can be explained by various factors including cancer type, drug dosage, synergism, bioavailability, patients lifestyle, tendency to take supplements, and the duration of the studies with other variables incorporated (67) (Table 7)