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Furthermore, PRDX4 negatively regulates OS levels in order to protect GSCs from cell death and increase resistance to treatment (Kim et al., 2014)

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At 21 dpf, the above-mentioned flat and replete ticks and mouse tissues were then used to determine bacterial burdens and the tibiotarsus joints were used to determine the severity of arthritis in the section Quantification of spirochete burdens and histological analysis of arthritis. Mouse sera were utilized to define the Lyme disease bacterial seropositivity as described in the section ELISAs. Quantification of spirochete burdens and histological analysis of arthritis DNA was extracted from the indicated mouse tissues to determine bacterial burdens, using quantitative PCR analysis as described (77)