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They have been shown to redistribute heavy metals from other tissues to the brain, increasing brain neurotoxicity and leading to the loss of essential metals, such as zinc, or even hepatotoxicity due to serious side effects due to hepatotoxicity (134)

Stupp et al

Consider the tick-borne Lyme disease, caused by the Borrelia burgdorferi bacteria, which sometimes manifests itself in bullseye pattern skin lesions, but can later progress to muscle dysfunction, arthritis, facial palsy, and more

Pyridoxine antagonists such as isoniazid, cycloserine, penicillamine, and hydralazine may decrease the efficacy of pyridoxine