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At Dermo Direct, we are frequently asked: What supplements can I take while on isotretinoin? Are there vitamins that help with dryness or side effects? Which supplements should I avoid? As a Dermatologist I often suggest that a lot of oral supplements are not needed whilst taking isotretinoin, as gentle skin care, emollient use and sunscreen/sun protection are the key focus areas for patients taking isotretinoin but if patients are struggling with certain side effects, some of the following supplements can help