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In a recent study, it was shown that patients with asthma who were well controlled with inhaled corticosteroids and long-acting 2 agonists had higher lipid peroxide levels compared with healthy controls [113]

Furthermore, this systemic exposure was corroborated by significant pathological damage in the sensitive retinal tissue, typically observed as cytotoxic edema

These evidence, while observed in cardiomyocytes and vascular smooth muscle cell metabolism, is also applicable to explain other important system functional imbalance in the lipotoxic state of high FFAs

However, a series of issues, such as whether ferroptosis produces drug resistance and/or off-target effects, and how to improve selectivity in the treatment of HNC, are worthy of careful consideration