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This response is characterised by upregulation of several cytoprotective and detoxification genes, including ferritin, GSH- S -reductase (GSR), GST, GCLM, and GCLC, phase-I drug oxidation enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), MRP, and heme oxygenase-1 (HO-1) [78, 79]

2.3.3 Sarcopenia and osteoporosis in elderly diabetes Sarcopenia is a progressive, systemic skeletal muscle disorder that is associated with an increased risk of adverse outcomes such as falls, fractures, physical disability, and mortality (Schaap et al., 2018)

Are there any inducers or inhibitors that can target ferroptosis for the treatment of OA

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