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Although statistical association methods have identified many common variants that correlate with (and in some cases cause) human disease, correlational methods are typically futile for rare variants

The use of targeting ligands, such as angiopep-2, TAT or EGF, allows their accumulation to be increased in these specific areas [70,78,107,176]

We intend to investigate this further. The results also confirmed previous studies which found a positive association between pre-diagnostic IGF-1 levels and colorectal, breast and prostate cancer, including a study led by Professor Tim Key at CEU and IARC

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