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A murine study involving 250 mg/kg/daily AOD9604 and 1mg/kg/day HGH for 14 days reported that obese mice lost 28% and 40% of their body weight, respectively [21]

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The efficacy of lorcaserin appears similar to that of orlistat (mean difference in weight loss between active and placebo treated groups approximately 3 to 4 kg) and perhaps slightly less than that of phentermine-topiramate