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Thus, to our knowledge, palmitoyl-L-carnitine may worsen tau pathology through direct metabolic effects and inflammation-mediated kinase activation, highlighting its multifaceted role in neuroinflammation, oxidative stress, and kinase dysregulation associated with AD

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Genetic variants influencing drug metabolism can facilitate the selection of pharmacological treatments, improving efficacy and reducing adverse effects

PKCdelta knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice