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Therefore, some studies have shown that the level of D-serine in the host may be related to neurological diseases, such as Alzheimers disease, cognitive dysfunction, schizophrenia, depression, and addiction (Holeek, 2022)

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Furthermore, the deletion of Bmal1 in the brain induced apoE expression (inhibiting, e.g., astrocytic clearance of A [73]), potentially elucidating how circadian disruption may increase A burden in the brain