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Cell (2017) 170(1):14257.e19

Primer on genes encoding enzymes in sialic acid metabolism in mammals

Given that cyanide exposure from linamarin is strongly associated with the development of konzo, an increase in plasma oxidative stress may also affect cyanide action or metabolism, potentially amplifying its capacity to induce mitochondrial stress or giving rise to its oxidized form cyanate, which is a strong neurotoxin in various experimental models that can further decrease glutathione levels in the CNS 52,53