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In an ideal pH environment, the B12 can release from haptocorrin and bind to an important protein called intrinsic factor

Am J Physiol 269:R1204R1212 Federici M, Porzio O, Lauro D et al (1998) Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity

These three are targets because their cells either have a high turnover rate (blood and intestinal lining) or need a lot of B12 to function smoothly (nervous system)

VidalAlaball J, Butler C, CanningsJohn R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A