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Histopathological changes of vestibulocochlear nerve tissue was defined as presence of degenerated myelinated nerve fibers, dilatation of the vessel, congestion and collagen deposition

TGF- is activated through interactions with glycoprotein A repetitions predominant (GARP), integrins, proteases, and other TGF--binding proteins, enabling its subsequent binding to the TGF- receptor family (TR) [36]

IL-1 and IL-6 are key pro-inflammatory cytokines that trigger local inflammatory responses and tissue damage, while IL-4 and IL-10 are major anti-inflammatory cytokines that inhibit the production of pro-inflammatory factors and promote the resolution of inflammation ( NF- B pathway components in the reproductive organs compared with other tissues, a hypothesis that warrants further investigation in future mechanistic studies

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