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Firstly, the fragmented nature of mechanistic explanations is striking: existing studies tend to concentrate on isolated pathways (eg, activation of the GABAergic system, modulation of melatonin synthesis, or suppression of oxidative stress), yet the overarching mechanism through which magnesium influences sleep architecture via cross-system crosstalksuch as the synergistic interplay of neurotransmitter balance, circadian rhythm control, and inflammatory responseshas yet to be clarified

Aptamers: Aptamers are single-stranded nucleic acids that can be targeted to specific receptors or cells [59,60]

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We found a significant increase in the ratio of ferrous iron versus ferric iron (Fe 2+ /Fe 3+ ) in CSF of MS patients (Fig