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The putative role of mTOR inhibitors in non-tuberous sclerosis complex-related Epilepsy

Di Mauro M, Russo GI, Della Camera PA, Di Maida F, Cito G, Mondaini N, et al

The decreased activity of this complex at ZT4 could be the result of a deficient SIRT3-dependent deacetylation of the complex II catalytic subunit SDHA in cKOt mice caused by the decrease in NAD + concentration (45, 46)