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doi: 10.1016/j.actbio.2021.09.014 43 LiXGaoYLiuXHuXLiYSunJet al

1 In stage 3, the tissue becomes harder and more nodular compared to stages 1 and 2, where the skin remains relatively smooth

406 When GLP-1R is knocked out in astrocytes, it activates an integrated stress response, which affects the overall metabolic state by increasing the production of FGF21

Recent studies indicate that serotonin metabolism is involved in ferroptosis, a regulated form of cell death characterized by oxidative stress and uncontrolled phospholipid peroxidation [11,12,13,14]