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UK Guidance on Interpreting HbA1c Alongside B12 Status WHO 2011 guidance and NICE NG28 state that HbA1c should not be used for diagnosis when red blood cell turnover is abnormal

The following graphic depicts common symptoms and the organ systems affected

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Reconstituting with larger solvent volumes (45mL) improves measurement precision for low doses but depletes the vial faster across multiple injections